It's harder but we're still finding oil in Oklahoma today. The bar has been raised on startup companies but it can still be done. Every regulation and every rule limits you but yes it can still be done. That's the beauty of living in a free country and having the freedom to have an idea and become an entrepreneur.
I'm not on the run from anything and I'm not at all clear about what I'm running towards. But as some great writer put it I want to be certain that when I arrive at death I'm totally exhausted.